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South Asians at greatest risk for heart attack

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Old 05-05-2008, 12:19 PM
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Default Re: South Asians at greatest risk for heart attack

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Originally Posted by sally View Post
is he like pathan? memons hate pathans! jk.
Yes he is. And I hate you too (j/k)
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Old 05-05-2008, 12:24 PM
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Default Re: South Asians at greatest risk for heart attack

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Originally Posted by ChotooMotoo View Post
Yes he is. And I hate you too (j/k)
haha. i like pathans because the ones i grew up with and was exposed to always always tended to have a much more healthy bunch of food on their dinner table than most other types of desis.


this is sort of refreshing

year = 1999

Cardiovascular disease risk factors in 2 distinct ethnic groups: Indian and Pakistani compared with American premenopausal women -- Kamath et al. 69 (4): 621 -- American Journal of Clinical Nutrition

Cardiovascular disease risk factors in 2 distinct ethnic groups: Indian and Pakistani compared with American premenopausal women1,2,3
Savitri K Kamath, Erum A Hussain, Daxa Amin, Erica Mortillaro, Barbara West, Charles T Peterson, Faustina Aryee, Genoveva Murillo and D Lee Alekel

Background: Although people from the Indian subcontinent have high rates of cardiovascular disease (CVD), studies of such in Indian and Pakistani women living in the United States are lacking.

Objective: This study accounted for variability in serum lipid (total cholesterol and triacylglycerol) and lipoprotein [LDL cholesterol, lipoprotein(a), and HDL cholesterol] concentrations in Indian and Pakistani compared with American premenopausal women in the United States. Body composition, regional fat distribution, dietary intake, and energy expenditure were compared between groups.

Design: The 2 groups were 47 Indian and Pakistani and 47 American women. Health was assessed via medical history, physical activity, body composition (via anthropometry and dual-energy X-ray absorptiometry), dietary intake (via 7-d food records), and serum lipids.

Results: Serum total cholesterol, triacylglycerol, LDL cholesterol, lipoprotein(a), the ratio of total to HDL cholesterol, and the ratio of LDL to HDL cholesterol were greater (P <0.03), whereas HDL-cholesterol values were lower (P = 0.011) in Indians and Pakistanis than in Americans. Multiple regression analysis indicated that 18% of the variance in total cholesterol (P = 0.0010) and LDL cholesterol (P = 0.0009) was accounted for by ethnicity, energy expenditure, and the ratio of the sum of central to the sum of peripheral skinfold thicknesses. Ethnicity, sum of central skinfold thicknesses, ratio of polyunsaturated to saturated fat, and monounsaturated fat intake accounted for 43% of the variance in triacylglycerol concentration (P 0.0001). Monounsaturated fat, percentage body fat, and alcohol intake accounted for 26% of variance in HDL cholesterol. Ethnicity contributed 22% of the 25% overall variance in lipoprotein(a).

Conclusions: Results suggest that these Indian and Pakistani women are at higher CVD risk than their American counterparts, but that increasing their physical activity is likely to decrease overall and regional adiposity, thereby improving their serum lipid profiles.


BUT
Coronary artery disease risk factors in south Asian and American premenopausal women -- Singh 70 (6): 1112 -- American Journal of Clinical Nutrition

American Journal of Clinical Nutrition, Vol. 70, No. 6, 1112-1113, December 1999
© 1999 American Society for Clinical Nutrition

--------------------------------------------------------------------------------

Letters to the Editor

Coronary artery disease risk factors in south Asian and American premenopausal women
Ram B Singh
Heart Research Laboratory, Medical Hospital and Research Centre, Civil Lines, Moradabad 10 (UP) 244001, India, E-mail: rbsingh@nde.vsnl.net.inoricn@nde.vsnl.net.in

Dear Sir:

We enjoyed very much the most interesting work of Kamath et al (1) on the cardiovascular disease risk factors of south Asian and American premenopausal women. Their study raises several important questions. It is not clear how many subjects were consuming trans fatty acids and Indian ghee nor how much of these substances were being consumed. These substances are known to have adverse effects on coronary artery disease (2). trans Fatty acids also cause increases in lipoprotein(a) [Lp(a)] (3) and n-3 fatty acids from fish oil can decrease Lp(a) concentrations. It would be interesting to know the intake of n-3 fatty acids in the 3 groups. It is not clear why Indians and Pakistanis had lower plasma insulin concentrations than the Americans, despite having greater abdominal fat and lower physical activity levels than the Americans, factors which are known to predispose hyperinsulinemia (4).

People of south Asian origin are accustomed to consuming low-fat diets (<20% of energy/d) and having physically demanding occupations (5). In one population survey (6, 7), of 3257 Indian women aged 25–64 y we found that coronary artery disease risk factors, including dietary fat intake, were significantly greater in the higher social classes 1 and 2 than in the lower social classes 3–5. There were no significant differences in fruit and vegetable intakes between social classes, indicating that dietary fat intake and physical inactivity may be important determinants of coronary artery disease risk in people of south Asian origin. One cross-sectional survey of 515 rural and 595 urban subjects showed that plasma concentrations of HDL were comparable in both men (1.18 ± 0.13 and 1.21 ± 0.22 mmol/L, respectively) and women (1.21 ± 0.16 and 1.28 ± 0.24 mmol/L, respectively) (8). However, 2-h plasma insulin was significantly higher in urban men and women than in rural subjects, indicating that it may be influenced by environmental factors (Table 1). Plasma concentrations of total cholesterol and triacylglycerols were significantly greater in urban than in rural subjects (Table 1). In a more recent study, plasma zinc concentrations and zinc intakes were inversely associated with high Lp(a) concentrations, indicating that poor zinc intake may cause increased Lp(a) concentrations more in urban than in rural subjects (9). In a randomized, single-blind controlled trial in 463 patients, we showed that a fat-reduced diet plus moderate physical activity decreased plasma insulin and associated disturbances, resulting in significant reductions in cardiac events (10).
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Old 05-05-2008, 12:33 PM
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Default Re: South Asians at greatest risk for heart attack

this is scary b/c my Caucasian side of the family has a history of obesity and all the related illnesses that go along with that (blood pressure, heart issues, diabetes) and my desi side of the family has a strong history of diabetes (non-obesity related). So in my case, regardless of the race both sides are doomed to health problems. Umm... I guess I should be going to a detox farm right about now and living a raw vegetable lifestyle forever? Sally? I'm scared. Can I still change and avoid that stuff?
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Old 05-05-2008, 02:22 PM
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Default Re: South Asians at greatest risk for heart attack

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Originally Posted by thejellymill View Post
this is scary b/c my Caucasian side of the family has a history of obesity and all the related illnesses that go along with that (blood pressure, heart issues, diabetes) and my desi side of the family has a strong history of diabetes (non-obesity related). So in my case, regardless of the race both sides are doomed to health problems. Umm... I guess I should be going to a detox farm right about now and living a raw vegetable lifestyle forever? Sally? I'm scared. Can I still change and avoid that stuff?
well, for what it's worth, since you're a hybrid/ half breed, you must have a pretty decent bunch of genes and disease resistance and all that jazz

and i think i made some of that up...but i'm pretty sure i've read that somewhere.

anyway it's always just a good idea to eat balanced meals and up the cardio and light weight training and leave the rest to Allah cuz there's only so much you can do
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Old 05-05-2008, 02:26 PM
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Default Re: South Asians at greatest risk for heart attack

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Originally Posted by sally View Post
anyway it's always just a good idea to eat balanced meals and up the cardio and light weight training and leave the rest to Allah cuz there's only so much you can do
Yea.. from that guy's story his lifestyle's way more active and healthy than mine and he was still getting operated on at such a young age!
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Old 05-06-2008, 09:08 AM
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Default Re: South Asians at greatest risk for heart attack

This article is related,but not toronto based -- and is in the UK
If our generation doesn't take the warnings that come with this stuff, we're going to be in trouble.


-----------------------================================--------------------------------


BBC NEWS | Health | Genes 'up Indians' obesity risk'
Page last updated at 10:10 GMT, Tuesday, 6 May 2008 11:10 UK

Genes 'up Indians' obesity risk'

Scientists have pinpointed a reason why people with Indian ancestry may be more prone to weight problems.

They have found this group is more likely to carry a gene sequence linked to an expanding waist line, weight gain and type 2 diabetes.

The sequence, discovered by a team led by Imperial College London, is carried by 50% of the population - but is a third more common in Indian Asians.

It is hoped the Nature Genetics study could lead to new obesity treatments.


"This study is important because it provides a potential genetic 'flag' by which doctors may be able to identify people who would gain great health benefits from help to avoid gaining weight" Professor Peter Weissberg, British Heart Foundation

The finding might provide a possible genetic explanation for the particularly high levels of obesity in Indian Asians, who make up 25% of the world's population, but who are expected to account for 40% of global cardiovascular disease by 2020.

The gene sequence sits close to - and possibly influences - a gene called MC4R, which regulates energy levels in the body by influencing how much we eat and how much energy we expend or conserve, and which has been directly implicated in rare forms of extreme childhood obesity.

The researchers discovered that the sequence is associated with a 2cm expansion in waist circumference, a 2kg gain in weight, and a tendency to become resistant to insulin, which can lead to type 2 diabetes.

Preventative measures

Lead researcher Professor Jaspal Kooner said the genetics behind obesity and its related health problems had been little understood.

He said: "A better understanding of the genes behind problems such as diabetes and cardiovascular disease means that we will be in a good position to identify people whose genetic inheritance makes them most susceptible.

"We can't change their genetic inheritance. But we can focus on preventative measures, including life-style factors such as diet and exercise, and identifying new drug targets to help reduce the burden of disease."

Professor Peter Weissberg, medical director of the British Heart Foundation, which funded the study, said it had long been established that Indian Asians were more susceptible to heart disease than white Europeans.

He said: "This study is important because it provides a potential genetic 'flag' by which doctors may be able to identify people who would gain great health benefits from help to avoid gaining weight.

"Secondly, the findings give us new insights into the biology that makes some people more susceptible to heart disease than others.

"It is one of several recent genetic studies that promise to shed new light on the causes of heart disease and how to avoid it."
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Old 05-06-2008, 09:43 AM
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Default Re: South Asians at greatest risk for heart attack

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Originally Posted by Rambo View Post
^ yes i agree, for example our local kashmiri diet is much healthier then other south asian groups
you're kashmiri? o.o
Quote:
Originally Posted by sally View Post
i can't judge because other than wazwaan and kashmiri chai i have no idea what kashmiri cuisine entails
you've had waz waan?

i hate lamb
unless it's cooked lebanese style. then it's amazing (sometimes)
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Old 05-29-2008, 12:29 AM
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Default Re: South Asians at greatest risk for heart attack

This article details the diff. between Visceral fat (abdomen fat skinny Indians have) vs Subcatenous fat (found in sumo wrestlers) and why visceral fat is more dangerous

The Hindu : Trimness no guarantee to health

Quote:
MEDIA IN general and doctors in particular have always driven home the point that obesity spells danger to individuals. Not surprising that most individuals who are obese have some health problem. Imagine what health problems that the sumo wrestlers who may make any obese person look trim in comparison may suffer. Now pit the sumo wrestlers with a really trim Asian Indian and who do you say will be more prone to say Type 2 diabetes? The answer seems simple and in all probability you would have got it wrong. In all likelihood it is the trim Asian Indian who may be a diabetic already or is likely to become one.

Shocking yet true. Studies abroad have revealed that sumo wrestlers do not suffer from Type 2 diabetes while a trim looking Asian Indian may in all probability suffer from it. The reason — subcutaneous fat which makes a person look obese is relatively benign compared to visceral fat. The trim Indian with huge visceral fat in the body is `metabolically obese'.

Visceral fat is the amount of fat stored in the abdominal cavity and seen around many organs in the abdominal cavity. These fat cells release fatty acids when not required by the body. As a result the fatty acid is less likely to be burned and instead gets accumulated in tissues and organs. The excessive exposure of tissues to fatty acids impairs the insulin function and increases blood insulin levels. "All this ultimately results in reduced insulin sensitivity making a person insulin resistant," said Dr. V. Mohan, Chairman and Managing Director of M.V. Diabetes Specialties Centre (P) Ltd., Chennai.



Subcutaneous fat that makes the person appear obese is metabolically less harmful and tends to release fatty acid only when the glucose and insulin level are relatively low and fat is needed as an energy source. It is well known that women are endowed with fat thighs and buttocks only to help them tide over energy requirements especially when they are pregnant. The visceral fat is particularly ominous to Indians as we are insulin resistant compared to Caucasians.

Coming back to the sumo wrestlers, the huge subcutaneous fat which makes them look very obese notwithstanding, their insulin sensitivity is near normal (and hence less insulin resistant). "This is because they have negligible visceral fat as they burn it by exercising daily," Dr. Mohan pointed out.

The link between visceral fat and insulin resistance was proved by CAT scan. Presence of huge visceral fat was found in those people who were insulin resistant than those of comparable body size. It was also found that the so-called lean type 2 diabetics had elevated visceral fat.

In the end the message appears loud and clear. No matter what, it is the distribution of fat (the place where it is found) which is of paramount importance than the amount of body fat when it comes to assessing the health of a person particularly diabetes. `Normal weight' in all probability should then not be a measure of one's health. "This is particularly true as all my studies and those done by others have shown Asian Indians to be more insulin resistant," Dr. Mohan said.

What then is the remedy? "Exercise," Dr. Mohan stressed, "as only that can help burn the visceral fat just like the sumo wrestlers." Any shortcut to reduce weight (fat) only helps in bringing about cosmetic effect and does no good to the person's well being. This message has to be borne in mind especially at a time when health centres promising to help reduce weight are mushrooming.. Waist size reduced by 10 inches. Happy? But what about your visceral fat lady? Walk your way to health instead.
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